If you're considering buying an RDX, it's generally recommended to look for models from recent years as they tend to have the latest safety features and technology.
When choosing between a two-wheel drive (2WD) top trim and a four-wheel drive (4WD), it depends on your driving conditions. If you're mostly driving on highways and in urban areas, a 2WD might be sufficient and could offer better fuel economy. However, if you want extra traction and stability, especially in adverse weather conditions, a 4WD would be a safer option.
In terms of safety, newer models typically have more advanced safety technologies. Always check the specific safety features available in the model year you're considering.